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Project # 6
Lens Power Influence on Intraocular Lens/Posterior Lens Capsule Interactions and PCO
| Team Lead: | Vicki Ea |
| Other Team Members: | |
| Faculty Advisor(s): | Dr. Liping Tang |
| Department: | BE |
| Project Type: | Graduate Student |
| Title: | Lens Power Influence on Intraocular Lens/Posterior Lens Capsule Interactions and PCO |
| Abstract: | Severely myopic eyes have been associated with high posterior capsule opacification (PCO) incidence and weaker/more delayed capsule adhesion than emmetropic eyes. However, it is unclear how power and posterior radius of curvature (PRC) of IOLs affect IOLs' affinity for the posterior lens capsule (PLC) and their PCO potential. Acrylic foldable IOLs with dioptric powers of 6.0D (for high myopia), 20.0D, and 30.0D (for low/non-myopia) were tested for PLC binding affinity and inhibition of lens epithelial cell (LEC) proliferation and infiltration in an in vitro simulated human PLC (sPLC) model. We found that IOL power and PRC had significant impacts on IOL/sPLC adhesion forces in the following order: 20.0D≈30.0D>6.0D. Optical coherence tomographs showed that loose binding between 6.0D IOLs and sPLC contributed to greater interface spaces and LEC infiltration/proliferation compared to 20.0D and 30.0D IOLs. Statistical analyses showed that IOLs' PRC may have a strong influence on IOL/sPLC physical interactions, LEC responses, and PCO incidence. The results suggest that high PRC of low diopter IOLs reduces their binding affinity toward the PLC and facilitates LEC reactions, thus causing high PCO incidence in myopic eyes. This new information may guide future IOL designs with decreased risk of PCO. |
| Poster: | View Poster #6 (PDF) |
| Judges Scoring: | Submit Evaluation (judges only) |