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Project # 30
Non-invasive Procedures to Assess Shoulder Tissue Regeneration Following Surgical Procedures

Team Lead: Briana von Hedemann-Kovscek
Other Team Members: Bhavya Vaish
Faculty Advisor(s): Dr. Liping Tang
Department: BE
Project Type: Other Undergraduate
Title: Non-invasive Procedures to Assess Shoulder Tissue Regeneration Following Surgical Procedures
Abstract: Shoulder tissue regeneration following injury remains challenging to assess due to the lack of reliable, non-invasive methods. Gait analysis, which measures parameters such as step difference, stride difference, and paw area, presents a potential solution. In this study, we applied gait analysis to evaluate tissue regeneration in rats with glenoid labral tears treated with a platelet-derived growth factor (PDGF)-loaded adhesive. Gait parameters were measured and compared across four treatment groups: suture only, bone marrow stimulation alone (BM), PDGF adhesive alone (ADH), and bone marrow stimulation combined with PDGF adhesive (BM+ADH). ImageJ software was used to quantify gait differences, including variations in step symmetry, stride length, and paw area. To further investigate the relationship between gait patterns and tissue regeneration, histological analysis was performed to assess tissue composition, organization, and collagen deposition across treatment groups. These histological findings were then compared to the gait data to identify potential correlations between structural tissue changes and functional movement patterns. Gait patterns observed in labral injuries were compared with those in rotator cuff tendon injuries treated with the same adhesive. This study explores the potential of gait analysis as a non-invasive method for evaluating shoulder tissue regeneration and monitoring recovery outcomes.
Poster: View Poster #30 (PDF)
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